Evaluation of polymerase chain reaction, adenosine deaminase, and interferongamma in pleural fluid for the differential diagnosis of pleural tuberculosis. Use as a diagnostic and therapeutic tool request pdf. The diagnostic value of adenosine deaminase ada activity was studied to evaluate its use in the. Pdf on jan 1, 2006, santiago estrada and others published.
In addition, we failed to en counter a correlation between the adaactivity and. Estudio del liquido pericardico analisis clinicos pruebas. Tuberculosis is the principal cause of pleural exudates in countries with a high prevalence of this disease. Roux, university of stell en bosch, tygerberg hospital, republic of south mrica. Adenosine deaminase deficiency in two patients with severely impaired cellular immunity. Adenosin deaminasa ada, tuberculosis, pleural exudate. Inicio estudios laboratorio adenosin desaminasa en liquido pleural. Therefore evaluation of new fast and low cost diagnostics tools seems a good strategy in order to allow a specific treatment. Cerebrospinal fluid adenosine deaminase isoenzymes in meningeal tuberculosis diagnosis. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues its primary function in humans is the development and maintenance of the immune system.
The determination of the enzime of adenosine desaminase is a well studied test for the determination of tuberculosis infection. Distinguishing transudates from exudates through lights criteria is a pragmatic first step. A cross sectional study of patients presenting with pleural effusion were enrolled in the. To evaluate the usefulness of pleural fluid adenosine deaminase ada for diagnosing tuberculous pleural effusions in the spanish population, according to laboratory technique and cutoff point, and to compare the results with other populations. However, the full physiological role of ada is not yet completely understood. Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. Levels of activity of the enzyme adenosine deaminase in tuberculosis and nontuberculosis pleural effusions.
Pdf adenosine deaminase in tuberculous pleural effusion. Carretero sastre jl, martanez barredo f, alonso mallo e et al. Services on demand scielo scientific electronic library. Heli jaime barronpastor 1,2, ruth isela cisneroschinchay 1,2,3, alvaro julian marcelorodriguez 2,4. Levels of activity of the enzyme adenosine deaminase in. To show and prove the utility of the determination of adenosine deaminase levels ada and its isoenzymes ada1 and ada2 in the pleural. Pdf adenosin deaminasa ada en liquido cefalorraquideo. The activity of adenosine deaminase ada was investigated in pleural effusions from 10 patients with tuberculous pleurisy and 76 patients with pleural effusions of other aetiology. Adenosina deaminasa en lcr en pacientes vih y enfermedades. Adenosine deaminase also known as adenosine aminohydrolase, or ada is an enzyme ec 3. Routine pleural fluid pf evaluation usually includes differential cell count, protein, lactate dehydrogenase, glucose and adenosine deaminase determinations, cytology and, if infection is a concern, ph as well as bacterial and mycobacterial cultures. Diagnostic usefulness of adenosin deaminase ada and its. Combined use of pleural adenosine deaminase with lymphocyteneutrophil ratio. Adenosina deaminase wikipedia, a enciclopedia livre.
1228 196 82 354 1316 14 1406 945 249 259 1292 760 14 757 1352 306 352 481 1482 442 873 58 254 752 1168 1238 1268 529 1162 101 418 490 245 791 1496